The CXCR2/CXCL2 signalling pathway – An alternative therapeutic approach in high-grade glioma

Besides VEGF, alternative signalling via CXCR2 and its ligands CXCL2/CXCL8 is a crucial part of angiogenesis in glioblastoma. Our aim was to understand the role of CXCR2 for glioma biology and elucidate the therapeutic potential of its specific inhibition.

Source: European Journal of Cancer - January 12, 2020 Category: Cancer & Oncology Authors: G üliz Acker, Julia Zollfrank, Claudius Jelgersma, Melina Nieminen-Kelhä, Irina Kremenetskaia, Susanne Mueller, Adnan Ghori, Peter Vajkoczy, Susan Brandenburg Tags: Original Research Source Type: research