Diorganotin(IV) complexes derived from N-terminal methylation of Triapine: synthesis, characterization and antibacterial activity evaluation

Publication date: Available online 3 February 2020Source: Journal of Organometallic ChemistryAuthor(s): Cuili Xing, Yan Fang, Lei Jiang, Yahong Zhang, Mingxue LiAbstractThe reaction of diorganotin(IV) with ligands (HL1 = 3-aminopyridine-2-carbaldehyde N(4) methylthiosemicarbazone, HL2 = 3-aminopyridine-2-carbaldehyde N(4)-dimethylthiosemicarbazone) afforded two compounds [PhSn(L1)Cl2] (1) and [(Ph)2Sn(L2)Cl] (2), respectively. The compounds were characterized by elemental analysis, infrared spectrum, UV–vis spectrometry, and X-ray crystallography. The ligands and corresponding complexes were assayed for their in vitro pharmaceutical activity against different pathogenic strains of bacteria by disk diffusion method. The results demonstrate that 1–2 have remarkable antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). 1 exhibit higher antibacterial properties against S. aurenu (MIC = 0.00095 μg/mL) and E. coil (MIC = 0.0019 μg/mL). In the same experimental conditions, the two complexes display more potent activity relative to standard antibiotics Kanamycin and Ampicillin.Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research