Biomarkers help predict outcome in deadly lung disease

A Yale-led study has identified a gene expression profile that can predict outcomes and lead to better treatment for one of the most lethal lung diseases, idiopathic pulmonary fibrosis (IPF). The study appears in Science Translational Medicine. IPF causes progressive scarring of the lungs, leading to cough, shortness of breath, and potentially death. In most cases, the cause cannot be identified, and there is no cure other than a lung transplant. While some patients experience a progressive course that leads to death within one to two years, others experience a relative stable disease...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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Conclusion: The prevalence of respiratory symptoms and corresponding diagnoses varied between and within the countries. The proportion reporting a diagnosis of obstructive airway disease among individuals with respiratory symptoms varied, indicating differences in diagnostic patterns both between areas and by sex. PMID: 32475292 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
CONCLUSION: The analyses provides a real world approach to the management of acute or chronic cough in various clinical conditions with pro- or antitussive agents while avoiding their misuse in empirical settings. PMID: 32469706 [PubMed - as supplied by publisher]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Source Type: research
Conditions:   Delirium;   Confusion;   Mental Status Change;   Back Pain;   Hip Pain Chronic;   Chest Pain;   Asthma;   COPD;   Cellulitis;   Soft Tissue Infections;   Cough;   Deep Vein Thrombosis;   Pulmonary Embolism;   Venous Thromboembolism;   Dyspnea;   Electrolyte Metabolism  Abnormal;   Fever;   Failure to Thrive;   Weakness;   Protein-Calorie Malnutrition;   Headache;   Neck Pain;   Hypoxia;   Pneumonia; &nb...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurpose of ReviewThis systematic review and meta-analysis evaluated the association between asthma and mouth breathing. We performed a systematic search in the PubMed, SCOPUS, Lilacs, Web of Science, Google Scholar and OpenThesis databases.Recent FindingsAsthma is defined as a heterogeneous disease characterized by variable symptoms of wheezing, shortness of breath, chest oppression and/or cough, and limitation of expiratory airflow. Although several studies have examined the association between asthma and mouth breathing, there are no systematic reviews or meta-analyses that synthesize the available bodies of evid...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
api A Abstract Cough, a defense mechanism for clearing the airways of secretions, exudate, or foreign bodies, may become a troublesome symptom. Chronic cough, one of the most frequent symptoms requiring medical attention, is often not due to identifiable causes in adults. Chronic productive cough defines chronic bronchitis, and thus is present in 100% of these patients, and frequently in patients with bronchiectasis, cystic fibrosis, and chronic infectious respiratory diseases. However, chronic cough is most frequently dry. Thus, chronic cough in adults is a difficult syndrome requiring multidisciplinary approache...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
Abstract This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug, formulation and device. The incidence of cough is typically less than 5% for drugs with a nominal dose less than 1 mg, including asthma and COPD therapeutics. Cough increases markedly as the dose approaches 100 mg. This is due to changes in the composition of epithelial lining fluid (e.g., increases in osmolality, proton concentration). Whether an individual exhibits cough depends on their degree of sensitization to mechanical and chemical stim...
Source: Advanced Drug Delivery Reviews - Category: Drugs & Pharmacology Authors: Tags: Adv Drug Deliv Rev Source Type: research
ConclusionCorticosteroids appear to restore the desensitization of the CR in OVA sensitized rabbits during artificial limb exercise, suggesting the potential role of airway inflammation in the pathophysiology of cough during exercise in asthmatics.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Since the first case of severe acute respiratory syndrome coronavirus 2 infection on January 22, 2020, the number of positive cases and deaths has rapidly increased.1 The initial report of 140 hospitalized patients infected with coronavirus disease 2019 (COVID-19) from Wuhan, China, indicated that allergic diseases, asthma, and chronic obstructive pulmonary diseases were not risk factors for severe acute respiratory syndrome coronavirus 2 infection.2 However, the clinical features of this condition with cough and shortness of breath (SOB) might mask, or mimic, an asthma exacerbation.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Since the first case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on January 22, 2020, the number of positive cases and deaths has rapidly increased.(1) The initial report of 140 hospitalized coronavirus (COVID-19) infected patients from Wuhan China indicated that allergic disease, asthma and chronic obstructive pulmonary disease were not risk factors for SARS-CoV-2 infection.(2) However, the clinical features of this condition with cough and shortness of breath might mask, or mimic, an asthma exacerbation.(3) Given the evolving nature of this pandemic, this initial summary may not represent the clinical...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
In this study, the anti-proliferation effect of petroleum extracts of FF (PEFF) against Lewis lung cancer (LLC) cells and the corresponding mechanisms were studied using cell metabolomics. Fifteen differential metabolites in the cell extracts and the corresponding medium related with the anti-proliferation effect of PEFF were identified, which were probably involved with the Pyruvate metabolism and Glycine, serine and threonine metabolism. For the cellular uptake compounds of PEFF, six metabolites derived from two prototype compounds, were also tentatively identified by UHPLC-Q-Orbitrap HRMS. Network pharmacology analysis ...
Source: Biomedical Chromatography : BMC - Category: Biomedical Science Authors: Tags: Biomed Chromatogr Source Type: research
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