Biomarkers help predict outcome in deadly lung disease

A Yale-led study has identified a gene expression profile that can predict outcomes and lead to better treatment for one of the most lethal lung diseases, idiopathic pulmonary fibrosis (IPF). The study appears in Science Translational Medicine. IPF causes progressive scarring of the lungs, leading to cough, shortness of breath, and potentially death. In most cases, the cause cannot be identified, and there is no cure other than a lung transplant. While some patients experience a progressive course that leads to death within one to two years, others experience a relative stable disease...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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Publication date: Available online 14 March 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): David Muccino, Stuart GreenAbstractChronic cough, or cough lasting>8 weeks, is often associated with underlying medical conditions (ie, asthma, gastroesophageal reflux disease, nonasthmatic eosinophilic bronchitis, and upper-airway cough syndrome). In some patients with chronic cough, treatment of these underlying conditions does not resolve the cough (refractory chronic cough [RCC]), or none of these conditions are present (unexplained chronic cough [UCC]). Despite appropriate medical evaluation, patients with RCC...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
[A CASE OF BRONCHIAL ASTHMA ASSOCIATED WITH BRONCHIOLAR EOSINOPHILIA AND TREATED WITH MEPOLIZUMAB]. Arerugi. 2019;68(2):101-106 Authors: Oyama B, Tsuburai T, Komase Y, Nishida K, Tsuruoka H, Usuba A, Muraoka H, Hida N, Mineshita M Abstract A 68 year-old woman with dyspnea and cough had been treated with inhaled corticosteroids for X-15 years, but her symptoms worsened in X year. High-resolution chest CT revealed small centrilobular nodules in the right upper lobe in March X year. The patient was diagnosed with asthma and diffuse panbronchiolitis and treated with inhaled corticosteroids, a long-acting ...
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
A 36-year-old man with no history of asthma and without a significant medical history presented with a 1-day history of a zosteriform burning rash on the right upper limb, cough, dyspnea, and wheezing. He reported numerous bed bugs bites in the previous week. The physical examination revealed moderate expiratory wheezing, excoriated pruritic papules and wheals on his lower limbs and head (Figure  1), and grouped papules and vesicles on an erythematous base on the right upper limb (Figure 2). The patient had a pulse of 88 beats/min, blood pressure of 116/78 mm Hg, and a respiratory rate of 19 breaths/min.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Visual Diagnosis in Emergency Medicine Source Type: research
High rates of air exchange associated with chronic cough, asthma, asthma - like symptoms
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Internal Medicine, Allergy, Nursing, Pediatrics, Pulmonology, Journal, Source Type: news
ConclusionsDVAS can be rapidly absorbed and excreted by blood, and it is also extensively metabolized in vivo, and the anti-BChE activity in blood is mainly attributed to DVAS. These findings can lay a foundation for new drug development for DVAS.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study aimed to determine the pathogenetic constituents and factors affecting UACS in children of different age groups, and to identify clinical clues for diagnosing UACS and a method for curative effect evaluation. METHODS: A total of 103 children with UACS whose chief complaint was chronic cough were studied from January to November 2013 at Children's Hospital, Capital Institute of Pediatrics. According to their age, children with UACS were divided into 3 groups: nursing children, pre-school children, and school-age children. We analyzed the differences in pathogenetic constituents and factors affecting UACS in ...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Publication date: Available online 6 March 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Ahmad Kantar, Manuela SeminaraAbstractRecently, there have been robust changes in our knowledge of the neurophysiology of cough and novel clinical etiologies. Specifically, cough hypersensitivity in adults and protracted bacterial bronchitis (PBB) in children have been increasingly investigated, and differences between chronic cough in children and adults have been widely reported. In young children, postinfectious cough, bronchiectasis, airway malacia, PBB, and asthma appear to be the main causes of cough; however, by...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
rfel Robert M. Brackbill Thousands of lower Manhattan residents sustained damage to their homes following the collapse of the Twin Towers on 11 September 2001. Respiratory outcomes have been reported in this population. We sought to describe patterns of home damage and cleaning practices in lower Manhattan and their impacts on respiratory outcomes among World Trade Center Health Registry (WTCHR) respondents. Data were derived from WTCHR Wave 1 (W1) (9/2003–11/2004) and Wave 2 (W2) (11/2006–12/2007) surveys. Outcomes of interest were respiratory symptoms (shortness of breath (SoB), wheezing, persis...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 2 March 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yunus Çolak, Shoaib Afzal, Peter Lange, Lars C. Laursen, Børge G. Nordestgaard, Morten DahlAbstractBackgroundCough is a well-recognized symptom in asthma, but the role and impact of chronic cough in individuals with asthma has not been described in the general population.ObjectiveWe hypothesized that among individuals with asthma, those with chronic cough versus those without have a more severe disease phenotype.MethodsWe identified individuals with asthma and chronic cough among 14,740...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
It’s hard to overstate the dangers of smoking. Nearly 500,000 people die of tobacco-related disease each year in the US. Over the next decade, estimates are that around eight million people will die prematurely worldwide each year due to tobacco use. The list of tobacco-related diseases and conditions is long and growing. It includes: cardiovascular disease, including heart attack and stroke emphysema, bronchitis, and asthma lung and other types of cancer tooth decay weathering of the skin having a low-birthweight baby diabetes eye damage (including cataracts and macular degeneration). And there are others. The poi...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Prevention Smoking cessation Source Type: blogs
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