Quanterix Advances Blood-Based Sports-Related TBI Test with New Study
Quanterix has reached another step in its goal to advance a blood-based test to detect concussions in athletes. The Billerica, MA-based company said researchers have successfully applied the Single Molecule Array (Simoa) technology to generate data on the value of blood biomarkers as research tools to study pathophysiological mechanisms of concussion and as potential clinical tools and objective indicators for sports-related concussions (SRCs) and mild traumatic brain injuries (mTBIs). Results have been published in JAMA Network Open, demonstrate the promise of blood biomarkers to serve as clinical tools for objectively identifying and monitoring head injury, marking a notable advance in the pursuit of a concussion diagnostic test. âWhat has gone on in this study is, weâre using our sensitivity of Simoa to look at mild traumatic brain injuries,â Kevin Hrusovsky, Chairman and CEO, Quanterix, told MD+DI. âThose two markers that were used in this study -were approved by FDA [about two years ago] to rule out the need to use a CT Scan in the event of a TBI and the company that [behind] that was Banyan Diagnostics.â Results of the study demonstrate a strong correlation between concussions and elevated GFAP, UCH-L1 and tau levels in the blood. The company said this supports prevailing theories that a clinically viable concussion test will necessitate a panel of markers rather than relying on a ...
We report a case of the pathologically evaluated antitumor effect of pembrolizumab, a programmed death-1 immune checkpoint inhibitor antibody, in G-CSF-producing bladder cancer. A 53-year-old male patient underwent 4 courses chemotherapy with a combination of gemcitabine and carboplatin before a radical cystectomy with ileal neobladder. Four months after the surgery, local recurrence was detected in the pelvis and therefore pembrolizumab was used. One week after its administration, the patient showed increased mucus in his urine. A computed tomography scan and cystoscopy revealed a fistula between the ileum and the neoblad...
Conclusions: M1 disease at PC diagnosis was associated with worse survival after CRPC onset versus M0. Higher Gleason score at diagnosis was associated with higher mortality after CRPC onset in M0 patients at diagnosis. PMID: 32266854 [PubMed - as supplied by publisher]
CONCLUSIONS: Large ranges of FOV and PKA were found for a given indication, demonstrating the importance of establishing DRLs as well as FOV recommendations in view of optimizing the present practice. For now, only DRLs for dental and maxillofacial could be defined; because of a lack of ENT data, no DRL values for ENT practices could be derived from this survey. PMID: 32267774 [PubMed - as supplied by publisher]
Phys. Chem. Chem. Phys., 2020, Advance Article DOI: 10.1039/C9CP06925A, PaperSumit Kumar Das, Tara Shankar Bhattacharya, Joydeep Chowdhury Wavelength-scanned SERS spectra of 4-mercaptopyridine molecule adsorbed on gold nanoparticles immobilised in a Langmuir Reverse Schaefer film of 5CB molecules. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CrystEngComm, 2020, Advance Article DOI: 10.1039/D0CE00086H, PaperHualan Xu, Ran Liu, Yongmei Zhu, Jinjiang Li, Changfeng Wan, Hang Zhang, Chuying Ouyang, Shengliang Zhong Scandium-based coordination polymer octahedrons with concaved surfaces have been fabricated. The formation mechanism was also investigated. Sc2O3 octahedrons were obtained after simple calcination in a N2 atmosphere. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
The virus's tool for prying open host cells is coated in a protective armor of sugar--but gaps may offer vulnerability to disruption by antibodies.
Background: Reduced bone mineral mass by dual x-ray absorptiometry is reported in children living with HIV (CLWH), but few studies of bone microarchitecture, particularly in sub-Saharan Africa, have been conducted. Here, we compare bone architecture and strength in black South African CLWH and uninfected control children by peripheral quantitative computed tomography (pQCT). Setting and Methods: One hundred seventy-two CLWH on antiretroviral therapy (ART) and 98 controls in the CHANGES Bone Study in Johannesburg, South Africa received pQCT scans of the radius and tibia. Measurements included trabecular and cortical vo...
The makers of specialized cameras to quickly scan for fevers as people enter crowded workplaces are grappling with soaring demand while confronting supply disruptions, forcing some to prioritize customers such as hospitals, executives told Reuters.
Conclusion: CCT was able to identify the presence of SCAD in most of the patients in the acute phase of this elusive and challenging clinical entity. In addition, in this setting, CCT revealed unique and distinct radiologic features and provided a precise assessment of lesion severity.
Conclusions: Macrostructural abnormality on CT was associated with worse functional outcome at one week post MTBI. PMID: 31550173 [PubMed - as supplied by publisher]