Adrenocortical hyperplasia: a multifaceted disease

Publication date: Available online 4 February 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Isabelle Bourdeau, Stéfanie Parisien-La Salle, André LacroixAbstractAdrenocortical hyperplasia may develop in different contexts. Primary adrenal hyperplasia may be secondary to primary bilateral macronodular adrenocortical hyperplasia (PBMAH) or micronodular bilateral adrenal hyperplasia (MiBAH) which may be divided in primary pigmented nodular adrenocortical disease (PPNAD) and isolated micronodular adrenocortical disease (i-MAD). Both lead to oversecretion of cortisol and potentially to Cushing’s syndrome. Moreover, adrenocortical hyperplasia may be secondary to longstanding ACTH stimulation in ACTH oversecretion as in Cushing’s disease, ectopic ACTH secretion or glucocorticoid resistance syndrome and congenital adrenal hyperplasia secondary to various enzymatic defects within the cortex. Finally, idiopathic bilateral adrenal hyperplasia is the most common cause of primary aldosteronism. We will discuss recent findings on the multifaceted forms of adrenocortical hyperplasia.

Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 4, 2020 Category: Endocrinology Source Type: research