Use of a Temperature Ramp Approach (TRA) to Design an Optimum and Robust Freeze-drying Process for Pharmaceutical Formulations

In this study, a successful freeze-drying process of two model formulations using the TRA was designed. Verification experiments at the optimum processing conditions showed excellent agreement in both product temperature and sublimation rate with the values obtained using the TRA. Thus, the TRA detailed in this study offers a significant advantage to reduce development time and material and enhance the efficiency and robustness of the resulting freeze-drying process.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research