MicroRNA ‐153‐3p regulates cell proliferation and cisplatin resistance via Nrf‐2 in esophageal squamous cell carcinoma

ConclusionMiR ‐153‐3p inhibits cell proliferation and confers cisplatin resistance by downregulating Nrf‐2 expression in Eca‐109 cells. Thus, miR‐153‐3p/Nrf‐2 may play an important role in conferring cisplatin resistance in ESCC. Nrf‐2 appears to be a promising therapeutic target for ESCC.

Source: Thoracic Cancer - February 4, 2020 Category: Cancer & Oncology Authors: Jing Zuo, Mei Zhao, Zhisong Fan, Bowei Liu, Yudong Wang, Yuehong Li, Ping Lv, Lingxiao Xing, Xianghong Zhang, Haitao Shen Tags: ORIGINAL ARTICLE Source Type: research