Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors

ConclusionWe provide a rationale for manipulating the macrophage phenotype and increased the therapeutic effect of ICPi. To re-educate and re-empower the TAM/microglia opens an interesting avenue for GBM treatment.Graphic Abstract

http://link.springer.com/10.1007/s11060-019-03360-3

Source: Journal of Neuro-Oncology - January 31, 2020 Category: Cancer & Oncology Source Type: research