Comprehensive Assessment of Respiratory Complications in Patients with Common Variable Immunodeficiency.

Comprehensive Assessment of Respiratory Complications in Patients with Common Variable Immunodeficiency. Ann Allergy Asthma Immunol. 2020 Jan 30;: Authors: Moazzami B, Mohayeji Nasrabadi MA, Abolhassani H, Olbrich P, Azizi G, Shirzadi R, Modaresi M, Sohani M, Delavari S, Shahkarami S, Yazdani R, Aghamohammadi A Abstract BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some non-infectious clinical complications. OBJECTIVE: The current study aimed to provide a detailed evaluation of respiratory presentations and complications in a cohort of Iranian patients with CVID. METHODS: The present retrospective cohort study was conducted on 245 CVID patients who were recorded at the Iranian primary immunodeficiency disorders registry network. Respiratory manifestations were evaluated by reviewing clinical hospital records, immunologic findings, pulmonary function tests (PFT), and high-resolution computed tomography (HRCT) scans. RESULTS: The majority of patients (n=208, 85.2%) had experienced at least one episode of acute respiratory manifestation and pneumonia was observed in 31.6 % (n=77) of cases as a first disease manifestation. During the follow-up pneumonia, sinusitis and otitis media were documented in 166 (68.6%), 125 (51.2%) and 103 (42.6%) cases, respectively. Abnormal PFT measurements were documented in 53.8 % of patients. ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research

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