Long-term methylglyoxal intake aggravates murine Th2-mediated airway eosinophil infiltration.

In conclusion, 12-week intake of MGO exacerbates Th2-mediated airway eosinophil infiltration by activation of NF-kB/iNOS-dependent signaling pathway and positive regulation of NOX-2 and NOX-4 in the lung tissues. Scavengers of MGO could be an option to prevent obesity-related asthma. PMID: 32007798 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32007798?dopt=Abstract

Source: International Immunopharmacology - January 29, 2020 Category: Allergy & Immunology Authors: Medeiros ML, de Oliveira MG, Tavares EG, Mello GC, Anhê GF, Mónica FZ, Antunes E Tags: Int Immunopharmacol Source Type: research