Light-induced amaurosis – a case report and brief literature review.

Light induced amaurosis is a rare manifestation of symptomatic carotid artery disease. Unlike amaurosis fugax, which is often attributed to embolic phenomenon associated with carotid artery disease, light induced amaurosis has been associated with reduced perfusion to the eye, secondary to carotid artery disease, leading to retinal ischemia. The case described here is that of a 67-year-old male with bilateral vision loss in response to bright light. Imaging revealed severe internal carotid stenosis on the right and occlusion of the internal carotid artery on the left.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research

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Authors: Mitsui R, Hashitani H Abstract Spontaneous rhythmic constrictions known as vasomotion are developed in several microvascular beds in vivo. Vasomotion in arterioles is considered to facilitate blood flow, while venular vasomotion would facilitate tissue metabolite drainage. Mechanisms underlying vasomotion periodically generate synchronous Ca2+ transients in vascular smooth muscle cells (VSMCs). In visceral organs, mural cells (pericytes and VSMCs) in arterioles, capillaries and venules exhibit synchronous spontaneous Ca2+ transients. Since sympathetic regulation is rather limited in the intra-organ microve...
Source: Journal of Smooth Muscle Research - Category: Research Tags: J Smooth Muscle Res Source Type: research
AbstractObjectivesTo evaluate the association of magnetic resonance diffusion-weighted imaging (DwI) and dynamic contrast-enhanced perfusion-weighted imaging (DCE-PwI) with a temporal resolution of 5  s, wash-in  30% in the evaluation of salivary glands neoplasms.MethodsDwI and DCE-PwI of 92 salivary glands neoplasms were assessed. The apparent diffusion coefficient (ADC) was calculated by drawing three regions of interest with an average area of 0.30 –0.40 cm2 on three contiguous axial sections. The time/intensity curve was generated from DCE-PwI images by drawing a region of interest that included ...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Menthol is a monoterpene alcohol, widely used in several food and healthcare products for its particular odor and flavor. For some decades, menthol has been known to act on the vasculature directly in the endothelium and vascular smooth muscle, with recent studies showing that it also evokes an indirect vascular response via sensory fibers. The mechanisms underlying menthol’s vascular action are complex due to the diversity of cellular targets, to the interplay between signaling pathways and to the variability in terms of response. Menthol can evoke either a perfusion increase or decrease in vivo in different vascula...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Stefano Fais Salvador Harguindey Stephan J. Reshkin Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons through fermentative glycolysis. This leads to extracellular acidosis and intracellular alkalinization. Dysregulated pH dynamics influence cancer cell biology, from cell transformation and tumorigenesis to proliferation, local growth, invasion, and metastasis. Moreover, this dysregulated intracellular pH (pHi) drives a metabolic shift to increased aerobic glycolysis and reduced mito...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
AbstractDecreased blood perfusion at the anastomotic site increases the risk of anastomotic leakage (AL) following colorectal surgery. Indocyanine green near-infrared fluoroangiography (NIRF/ICG) is a technique that allows for the assessment of intestinal perfusion before and after the formation of an anastomosis. We aimed to compare the rate of AL after colorectal surgery conducted with NIRF/ICG assessing vascular anastomotic perfusion and without this support. The data of patients who underwent colorectal surgery from November 2014 to February 2019 were reviewed retrospectively. Left-sided hemicolectomy, sigmoid resectio...
Source: Updates in Surgery - Category: Surgery Source Type: research
Abstract RATIONALE: Large decreases in PaCO2 that occur when initiating extracorporeal membrane oxygenation (ECMO) in patients with respiratory failure may cause cerebral vasoconstriction and compromise brain tissue perfusion. OBJECTIVES: To determine if the magnitude of PaCO2 correction upon ECMO initiation is associated with an increased incidence of neurological complications in patients with respiratory failure. METHODS: We conducted a multicenter international retrospective cohort study using the Extracorporeal Life Support Organization (ELSO) Registry, including adults with respiratory failure on a...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
This study aimed to evaluate the arch morphology of patients treated by TEVAR and requiring LSA coverage to determine the applicability of this OTS device.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
d C Abstract Podocytes are highly specialized cells with a clear cell polarity. It is known that in health and disease microvilli protrude from the apical surface of the podocytes into the urinary space. As a basis to better understand the podocyte microprojections/microvilli, the present study analyzed their spatial localization, extension and contact site with parietal epithelial cells (PEC). Using different electron microscopic (EM) techniques, renal corpuscules of male, young adult, healthy C57BL/6 mice fixed by vascular perfusion were analyzed. Serial block-face scanning EM was used to visualize entire corpus...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
We report a case of bilateral complete occlusion of the extracranial portions of the internal carotid arteries in a HIV+ve patient who presented with a syncopal episode due to intraventricular haemorrhage. Compensatory blood flow from the posterior cerebral circulation via the circle of Willis resulted in small telangiectatic vessels arising from the posterior cerebral circulation which probably accounted for this rare haemorrhagic complication of an occlusive arteriopathy. PMID: 32243116 [PubMed - as supplied by publisher]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
Conclusions: While the ophthalmic community has traditionally viewed glaucoma as the classic ocular anomaly of CMTC, this dataset advocates for the prompt investigation of posterior segment abnormalities as well. However, our understanding of CMTC's ocular anomalies is complicated by a lack of reporting and/or incomplete (or nonexistent) ophthalmic examinations, and we strongly encourage comprehensive ophthalmic examinations for all CMTC patients at the time of diagnosis, followed by appropriate screening and surveillance throughout life. We believe these recommendations will spur additional data and disease insights that ...
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
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