Physical exercise in the prevention and treatment of Alzheimer's disease: Exercise in Alzheimer's Disease

Publication date: Available online 4 February 2020Source: Journal of Sport and Health ScienceAuthor(s): De la Rosa Adrian, Olaso-Gonzalez Gloria, Arc-Chagnaud Coralie, Millan Fernando, Salvador-Pascual Andrea, García-Lucerga Consolacion, Blasco-Lafarga Cristina, Garcia-Dominguez Esther, Carretero Aitor, Correas Angela G, Viña Jose, Gomez-Cabrera Mari CarmenAbstractDementia is one of the greatest global challenges for health and social care in the 21st century. Alzheimer's disease, the most common type of dementia, is by no means an inevitable consequence of growing old. Several lifestyle factors may increase, or reduce, an individual's risk of developing Alzheimer's.Much has been written over the ages about the benefits of exercise and physical activity. Among the risk factors associated with Alzheimer's disease is a low level of physical activity. The relationship between physical and mental health was established several years ago.In this review, we will discuss the role of exercise (aerobic and resistance) training as a therapeutic strategy for the treatment and prevention of Alzheimer's disease. Older adults who exercise are more likely to maintain cognition. We will address the main protective mechanism on brain function modulated by physical exercise (PE) by examining both human and animal studies. We will pay especial attention to the potential role of exercise in the modulation of Amyloid beta (Aβ) turnover, inflammation, synthesis and release of neurotrophins, an...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research