Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function.

Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function.
Trends Immunol. 2020 Jan 29;:
Authors: Salerno F, Turner M, Wolkers MC
Abstract
Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8+ T cells. We discuss the dynamic features of post-transcriptional control during CD8+ T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses.
PMID: 32007423 [PubMed - as supplied by publisher]

Source: Trends in Immunology - January 28, 2020 Category: Allergy & Immunology Authors: Salerno F, Turner M, Wolkers MC Tags: Trends Immunol Source Type: research