Developing Predictive Biomarkers Goes Alongside Diagnostic Biotypes in Major Depressive Disorder

Major depressive disorder is the most common psychiatric disorder and is a leading cause of disease burden worldwide. Pharmacological and psychological therapies are considered first-line treatments. However, at least one third of patients fail to achieve remission despite a full course of pharmacological or psychological therapy, and persistent symptoms are associated with a higher risk of chronicity and recurrence (1,2). Clinical guidelines offer treatment recommendations based on empirical clinical trials, yet it is not possible to predict the efficacy of any treatment at the individual level.

Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Cynthia H.Y. Fu Tags: Commentary Source Type: research