Prenatal environment may influence brain disorders later in life

Alan Brown’s research links infections, chemical exposures, and inflammation in pregnancy to offspring’s schizophrenia, autism, and more. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news

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Abstract Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highlight the impact of SARS-CoV-2 (the coronavirus causing COVID-19) on the central nervous system as there is an urgent need to understand the longitudinal impacts of COVID-19 on brain function, behaviour and cognition. Furthermore, we address the possibility of intergenerational impacts of COVID-19 on the brain, potentially via both maternal and paternal routes. Evidence from preclinical models of earlier coronaviruses has shown direct viral infiltration across the blood-brain bar...
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
CONCLUSION: In this context, preventive measures and specialized care are necessary. Thus, it is important to propose a close follow-up to the individuals who have been infected by the virus, in order to set up the earliest care possible. Likewise, in pregnant women, screening of mood disorders during the pregnancy or the postpartum period must be facilitated. The follow-up of the babies born during the pandemic must be strengthened to screen and care for possible neurodevelopmental disorders. PMID: 32928535 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
DiscussionOur findings suggest that positive and disorganized schizotypy, in particular, have a relationship with affective lability. This, in turn, supports the idea of emotional processes as related to the development of schizotypal traits and psychosis across all individuals, regardless of autism diagnostic status. We found no evidence of empathy relating to any subscale of schizotypy, or the total schizotypy score. We contend that emotional processes should be considered in exploration of the relationship between autism and schizotypy in future. This may help to explain some of the findings of overlap between these con...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Taking choline supplements during pregnancy may reduce the negative impact of viral respiratory infections on offspring, according to astudy published in theJournal of Psychiatric Research.“The new analysis may provide information relevant to potential COVID-19 effects on fetal brain development and their interaction with higher prenatal maternal choline levels,” wrote Robert Freedman, M.D., of the University of Colorado School of Medicine and colleagues.Previous studies showed that infection in pregnant women can affect fetal brain development and may increase the risk of attention-deficit/hyperactivity disord...
Source: Psychiatr News - Category: Psychiatry Tags: ADHD autism choline COVID-19 infant behavior Infant Behavior Questionnaire-Revised infections Journal of Psychiatric Research prenatal supplements Robert Freedman schizophrenia Source Type: research
(University of California - Davis) The immune responses of a female mouse before pregnancy can predict how likely her offspring are to have behavioral deficits if the immune system is activated during pregnancy, according to researchers from UC Davis. The findings could help resolve what role serious infections during pregnancy play in the development of conditions such as autism and schizophrenia.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Abstract The prenatal environment, and in particular, the maternal-fetal immune environment, has emerged as a targeted area of research for central nervous system (CNS) diseases with neurodevelopmental origins. Converging evidence from both clinical and preclinical research indicates that changes in the maternal gestational immune environment can alter fetal brain development and increase the risk for certain neurodevelopmental disorders. Here we focus on the translational potential of one prenatal animal model - the maternal immune activation (MIA) model. This model stems from the observation that a subset of pre...
Source: Neurobiology of Disease - Category: Neurology Authors: Tags: Neurobiol Dis Source Type: research
This study investigated whether antenatal exposure to antidepressants (ADs) increases the risks of autism spectrum disorders (ASD), attention deficit/hyperactivity disorders (ADHD), schizophrenia and other mental illnesses, and cognitive and developmental deficits in infants or preschool children. PubMed, EMBASE, BIREME/BVS databases were searched to identify studies examining associations of ADs in pregnancy with neurodevelopmental and psychiatric disorders. Twenty studies addressed ASD and/or ADHD risks while 30 focused on developmental and cognitive deficits in infants or preschool children. Most studies detected no ass...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
In this episode, our hosts discuss whether or not mental illness is a real disorder or if it’s just something that medical and pharmaceutical companies made up to make a profit.  SUBSCRIBE &REVIEW “Instead of taking my psychiatric medications this morning, should I have just gone to yoga?” – Michelle Hammer Highlights from ‘Mental Illness Made Up’ Episode [2:00] Is mental illness real? [4:00] Yoga doesn’t cure all mental illnesses, just like it wouldn’t cure cancer. [16:00] Dealing with people who think mental illness is not real. [19:30] Eating disorders ar...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Brain and Behavior Disorders General Source Type: blogs
(Natural News) Your body needs essential vitamins and minerals to work properly. According to several studies, pregnant women need to get enough vitamin D to protect their babies from conditions such as autism and schizophrenia. Vitamin D: The “sunshine” vitamin Like calcium, vitamin D is essential for bone health. The vitamin helps lower a person’s risk for heart...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract Psychiatric disorders, such as schizophrenia and autism spectrum disorder, are associated with sleep disturbances and deficits in memory consolidation; however, the relationship between these symptoms remains unclear. Here, we focused on hippocampal sharp-wave ripples (SWRs), a form of transient high-frequency oscillations that occur during sleep and behavioral immobility and contribute to memory consolidation. We activated the maternal immune system with polyinosinic-polycytidylic acid (poly(I : C)), one of the major pharmacological models of psychiatric disorders, to investigate whether SW...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
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