Globus Pallidus Externus Deep Brain Stimulation Treats Insomnia in a Patient With Parkinson Disease

Sleep disorders are the second most common complaint in patients with Parkinson disease (PD), affecting up to 78.3% of patients and having severe impact on quality of life. Many patients fail hypnotic therapy or cognitive behavioral therapy for insomnia. In addition, many pharmacological treatments carry added risks in patients with PD (eg, increased risk of falls). The majority of existing studies exploring sleep outcomes in patients undergoing deep brain stimulation (DBS) for Parkinson disease in neuronal regions targeted for improvement of motor symptoms (eg, globus pallidus internus [GPi] and subthalamic nucleus [STN]) have shown no improvement —or even worsening—of objective sleep measures.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the editor Source Type: research

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CONCLUSIONS: Sleep deprivation can mimic cognition decline caused by insomnia with altered protein expression in the hippocampus; such behavioural and pathological changes can be significantly ameliorated by pearl powder. PMID: 32220128 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Authors: Zečević I Abstract Purpose of this review is to provide psychologists and other health care professional enough knowledge about available cognitive-behavioral interventions for comorbidities in Parkinson's disease that include depression, anxiety, impulsive disorder, pain and sleep disturbances. This review has clear clinical practical suggestions how to adapt psychological interventions and techniques to the motor and/or cognitive impairments of patients with Parkinson's disease, based on earlier available research results. Every available research that could be find with the help of search engines from...
Source: Clinical Psychology and Psychotherapy - Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research
CONCLUSION: There is an overlap, co-morbidity and interaction between anxiety, depression, sleep disorders and (non)motor symptoms, which warrants a multi-disciplinary approach to PD. Sleep disorders and cognitive dysfunctions may provide starting points for treatment and preventions of anxiety in PD. PMID: 31994713 [PubMed - in process]
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Tags: Tijdschr Psychiatr Source Type: research
AbstractObjectiveWe aimed to determine suicide risk and lifetime suicidal ideation in Parkinson disease (PD) patients versus controls and how depression, demoralization, and insomnia are associated with suicidality.MethodsIn this case –control study, PD patients and matched controls were recruited from movement disorder clinics, Michael J. Fox Foundation, and Research Match websites. Suicide risk and suicidal ideation were assessed using the Suicidal Behavior Questionnaire-revised (SBQ-R) and Columbia-Suicide Severity Rating Sc ale. Lifetime depression was assessed using the Brief Lifetime Depression Scale, sleep usi...
Source: Journal of Neurology - Category: Neurology Source Type: research
Sleep disorders are frequently diagnosed in Parkinson’s disease and manifested in the prodromal and advanced stages of the disease. These conditions, which in some cases affect more than 50% of Parkinson’s disease (PD) patients, include hypersomnia, often manifested as excessive daytime sleepiness, insomnia, characterized by delayed initiation and fragmentation of sleep at night, and disruption of rapid eye movement (REM) sleep, resulting in loss of atonia and dream enactment. Standard dopamine replacement therapies for the treatment of motor symptoms are generally inadequate to combat sleep abnormalities, whic...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Sleep disorders are common among PD patients and affect quality of life. They are often under-recognized and under-treated. Mechanisms of sleep disorders in PD remain relatively poorly understood. Improved awareness of common sleep problems in PD. Tailored treatment and evidence for efficacy are lacking. The purpose of this review is to provide an overview and update on the most common sleep disorders in PD. We review specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.
Source: Clinics in Geriatric Medicine - Category: Geriatrics Authors: Source Type: research
Conclusion: The PD patients showed a high prevalence of OSA, with the supine position exerting a significant influence on the OSA in these patients, and some factors that are associated with OSA in the general population did not seem to have a greater impact on PD patients.RESUMO A Apneia Obstrutiva do Sono (AOS) chega a acometer at é 66% dos pacientes com doença de Parkinson (DP), prevalência maior, portanto, que a da população geral. Embora seja mais prevalente, a relação entre AOS e DP permanence controversa, com trabalhos confirmando e outros afastando a relaç&atil...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Conclusions:ID comorbid to PD is associated with the classic psychological factors perpetuating ID in neurological disease-free individuals with insomnia. Target-oriented interventions for instance cognitive behavioral therapy for chronic insomnia should be considered as a treatment approach for ID comorbid to PD.Citation:Lebrun C, Gély-Nargeot M-C, Maudarbocus KH, Rossignol A, Geny C, Bayard S. Presleep cognitive arousal and insomnia comorbid to parkinson disease: evidence for a serial mediation model of sleep-related safety behaviors and dysfunctional beliefs about sleep.J Clin Sleep Med. 2019;15(9):1217–1224.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Publication date: Available online 14 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Rosanna Palmeri, Viviana Lo Buono, Lilla Bonanno, Chiara Sorbera, Vincenzo Cimino, Placido Bramanti, Giuseppe Di Lorenzo, Silvia MarinoAbstractSleep Disturbances are a non motor symptom very common in Parkinson’s Disease characterized by insomnia, worse quality of sleep and Excessive Daytime Sleepiness. Several factors have been associated with these disorders, especially neuropsychiatric symptoms, such as anxiety and depression.The aim of the study was to investigate the relationship between sleep quality and mood dis...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusions: The use of antidepressants, especially SNRIs, was associated with a shorter survival time of sCJD patients. The possible changes in neurotransmitters should be emphasized. Scientifically, this study may provide insights into the mechanism of CJD. Clinically, it may contribute to the early diagnosis of CJD.IntroductionDepression is common in the elderly. Its prevalence rate is as high as 11.19%, and this increases progressively with worsening cognitive impairment (1). The presence of depression is an acknowledged risk factor for dementia (2); it can even double the risk for Alzheimer’s disease (AD) (3, 4)...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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