New way to study pituitary tumors holds potential for better diagnoses and treatments

(Houston Methodist) Houston Methodist neurosurgeons are looking at a new way to classify pituitary tumors that could lead to more precise and accurate diagnosing for patients in the future. These tests also could have potential for better diagnoses in other brain tumors. The findings, published Jan. 28 in Scientific Reports, describe a new way to study the blood of pituitary adenoma patients to determine tumor type and whether they might respond to medical treatment rather than surgery.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 10 December 2019Source: Artificial Intelligence in MedicineAuthor(s): Sarah Ali Abdelaziz Ismael, Ammar Mohammed, Hesham HefnyAbstractCancer is the second leading cause of death after cardiovascular diseases. Out of all types of cancer, brain cancer has the lowest survival rate. Brain tumors can have different types depending on their shape, texture, and location. Proper diagnosis of the tumor type enables the doctor to make the correct treatment choice and help save the patient's life. There is a high need in the Artificial Intelligence field for a Computer Assisted Diagnosis (CAD) syste...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: March 2020Source: Biomedical Signal Processing and Control, Volume 57Author(s): Navid Ghassemi, Afshin Shoeibi, Modjtaba RouhaniAbstractIn this paper, a new deep learning method for tumor classification in MR images is presented. A deep neural network is first pre-trained as a discriminator in a generative adversarial network (GAN) on different datasets of MR images to extract robust features and to learn the structure of MR images in its convolutional layers. Then the fully connected layers are replaced and the whole deep network is trained as a classifier to distinguish three tumor classes. The deep neu...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
CONCLUSION: A highly focused imaging protocol is important for the diagnosis of sellar lesions such as pituitary tumors. The current favored modality is contrast-enhanced MRI, preferably with dynamic contrast-enhanced T1-weighted sequences. Early detection of the lesions and identification of the precise anatomical location are of great importance for diagnosis and therapy. PMID: 31321467 [PubMed - as supplied by publisher]
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Derin Gebhardt, 37, from Roundup, Montana, was diagnosed in May 2017 with a pituitary tumor, which was causing a decrease in normal levels of sex hormones and behind his infertility.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: This study demonstrated a rapid improvement of many symptoms in the subacute post-operative period in pituitary tumor patients. Disturbed sleep was identified as the only symptom to worsen post-operatively, encouraging potential prospective interventions to improve sleep, and subsequently improve the QOL in pituitary tumor patients following surgical intervention. Introduction Pituitary tumors are relatively rare primary central nervous system (CNS) tumors in adults (1) but make up 10% of all neurosurgical interventions in the United States (2). They are often an incidental finding in autopsies and brain...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Ramya Raman, Anantanarayanan RamanIndian Journal of Cancer 2018 55(4):424-427 A three-page paper entitled “A case of glioma (embryonal neurocytoma) of the brain simulating pituitary tumour,” written by K. G. Pandalai, Surgeon at the Madras General Hospital, and T. B. Menon, Pathologist at the Madras Medical College, was published in the Indian Medical Gazette. This paper refers to an occasional finding of a brain tumor (a glioma), presurgically diagnosed as a pituitary tumor, in 1928. This was close to the period when surgeons across the developed world believed in that cancers were by no means common among th...
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 18 October 2018Source: Biocybernetics and Biomedical EngineeringAuthor(s): Amin Kabir Anaraki, Moosa Ayati, Foad KazemiAbstractGliomas are the most common type of primary brain tumors in adults and their early detection is of great importance. In this paper, a method based on convolutional neural networks (CNNs) and genetic algorithm (GA) is proposed in order to noninvasively classify different grades of Glioma using magnetic resonance imaging (MRI). In the proposed method, the architecture (structure) of the CNN is evolved using GA, unlike existing methods of selecting a deep neural netw...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
In this study, the authors retrospectively examined the CP patient records available in the Cushing Brain Tumor Registry, as well as those CP cases reported by Cushing in medical monographs and scientific reports.RESULTSCushing's CP series comprises a total of 124 tumors (CP124) compatible with a CP diagnosis. Among this series are 92 cases that could be pathologically verified (CP92). This subcohort showed a bimodal age distribution (41% aged ≤ 19 years old) and a balanced sex distribution. Clinical evolution up to diagnosis was longer than 3 years in half of the patients. Typical symptoms found at diagnosis were sever...
Source: Journal of Neurosurgery - Category: Neurosurgery Tags: J Neurosurg Source Type: research
In conclusion, the current study demonstrated for the first time that inhibition of RWDD3 expression inhibited glioblastoma progression, at least partly, via suppressing the PI3K/AKT signaling activity, and thus RWDD3 may be a novel potential therapeutic target for glioblastoma. PMID: 29977365 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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