Muscle weakness in myositis: microRNAs mediate dystrophin reduction in MHC class I transgenic mouse model and human muscle biopsies
AbstractObjectiveMuscle inflammation is a feature in myositis and Duchenne Muscular Dystrophy (DMD). Autoimmune mechanisms are thought to contribute to myositis muscle weakness. However, the lack of correlation between inflammatory infiltrates and muscle weakness indicates a role for non ‐immune pathological mechanisms. We previously identified two microRNA sets elevated in DMD muscle. One is an “inflammatory” set that is dampened with glucocorticoids; the other is a “dystrophin‐targeting” set that inhibits dystrophin translation. Here we test the hypothesis that these m iRNAs are similarly dysregulated in myositis muscle and contribute to muscle weakness and disease severity.MethodsWe utilized the MHC class I transgenic myositis mouse model and validated findings in 6 myositis patient muscle biopsies. Mice were classified as mild or severe based on transgene expression, weight, histological severity, and muscle strength/weakness.ResultsSevere myositis mice show mononuclear cell infiltration along with elevated expression of Type 1 IFN and NF ‐B‐regulated genes including Tlr7 (3.8‐fold, p
Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Publication date: Available online 10 October 2020Source: Meta GeneAuthor(s): Mansour Zamanpoor, Hamid Ghaedi, Mir Davood Omrani
Publication date: October 2020Source: Brain, Behavior, and Immunity, Volume 89Author(s): Fernando Lopes, Fernando A. Vicentini, Nina L. Cluny, Alexander J. Mathews, Benjamin H. Lee, Wagdi A. Almishri, Lateece Griffin, William Gonçalves, Vanessa Pinho, Derek M. McKay, Simon A. Hirota, Mark G. Swain, Quentin J. Pittman, Keith A. Sharkey
BEST supplements to relieve joint pain: Is your arthritis playing up? The wetter and colder months could partially be to blame. These two pills may help.
CONCLUSIONS: Neuro-ophthalmologic findings are mostly normal in patients with visual snow syndrome. Retinal or neurological diseases must be excluded as possible causes of visual snow. PMID: 33029971 [PubMed]
CONCLUSION: When gastroenterologists encounter NAFLD/NASH patients, serum CK should be verified. If hyperCKemia, frontal baldness, a hatched face, history of cataract surgery, and grip myotonia are noted, the possibility of MD may be considered. PMID: 33033573 [PubMed]
Publication date: Available online 9 October 2020Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Hande Gurbuz Aytuluk, Kemal Tolga Saracoglu
ObjectiveMuscle inflammation is a feature in myositis and Duchenne muscular dystrophy (DMD ). Autoimmune mechanisms are thought to contribute to muscle weakness in patients with myositis. However, a lack of correlation between the extent of inflammatory cell infiltration and muscle weakness indicates that nonimmune pathologic mechanisms may play a role. The present study focused on 2 microRNA (miRNA ) sets previously identified as being elevated in the muscle of patients with DMD —an “inflammatory” miRNA set that is dampened with glucocorticoids, and a “dystrophin‐targeting” miRNA set that i...
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
ConclusionsEvaluating diseases remote from the gut would unfold the mysteries of the microbiome.