Relative Regional Air Volume Change Maps at the Acinar Scale Reflect Variable Ventilation in Low Lung Attenuation of COPD patients

Publication date: Available online 3 February 2020Source: Academic RadiologyAuthor(s): Kum Ju Chae, Jiwoong Choi, Gong Yong Jin, Eric A. Hoffman, Archana T. Laroia, Margaret Park, Chang Hyun LeeObjectivesThe purpose of this study was to investigate regional air volume changes at the acinar scale of the lung in chronic obstructive pulmonary disease (COPD) patients using an image registration technique.Materials and MethodsThirty-four emphysema patients and 24 subjects with normal chest CT and pulmonary function test (PFT) results were included in this retrospective study for which informed consent was waived by the institutional review board. After lung segmentation, a mass-preserving image registration technique was used to compute relative regional air volume changes (RRAVCs) between inspiration and expiration CT scans. After determining the appropriate thresholds of RRAVCs for low ventilation areas (LVAs), they were displayed and analyzed using color maps on the background inspiration CT image, and compared with the low attenuation area (LAA) map. Correlations between quantitative CT parameters and PFTs were assessed using Pearson's correlation test, and parameters were compared between emphysema and normal-CT patients using the Student's t-test.ResultsLVA percentage with an RRAVC threshold of 0.5 (%LVA0.5) showed the strongest correlations with FEV1/FVC (r = −0.566), FEV1 (r = −0.534), %LAA-950insp (r = 0.712), and %LAA-856exp (r = 0.775). %LVA0.5 was significa...
Source: Academic Radiology - Category: Radiology Source Type: research

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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 5.2 Monitoring Airway Disease Source Type: research
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Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Health Lung disease Smoking cessation COPD Source Type: news
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Source: European Radiology - Category: Radiology Source Type: research
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