Exome sequencing study of Russian breast cancer patients suggests a predisposing role for USP39

ConclusionsThis study suggests the role of a rare splicing variant inBC susceptibility.USP39 encodes an ubiquitin-specific peptidase that regulates cancer-relevant tumor suppressors including CHEK2. Further epidemiological and functional studies involving these gene variants are warranted.

Source: Breast Cancer Research and Treatment - January 31, 2020 Category: Cancer & Oncology Source Type: research