Multimodal 18F-AV-1451 and MRI Findings in Nonfluent Variant of Primary Progressive Aphasia: Possible Insights on Nodal Propagation of Tau Protein Across the Syntactic Network

Conclusion: Tau accumulation likely started in the more affected anterior node and, at the disease stage at which we studied these patients, appeared as well in the brain region (in the temporal lobe) spatially separate from but most connected with it. The arcuate fasciculus, connecting both of them, was most severely affected anteriorly, as would correspond to a loss of axons from the anterior node. These findings are suggestive of tau propagation from node to connected node in a natural human brain network and support the idea that neurons that wire together die together.

Source: Journal of Nuclear Medicine - February 2, 2020 Category: Nuclear Medicine Authors: Pascual, B., Funk, Q., Zanotti-Fregonara, P., Pal, N., Rockers, E., Yu, M., Spann, B., Roman, G. C., Schulz, P. E., Karmonik, C., Appel, S. H., Masdeu, J. C. Tags: Clinical Source Type: research