Zinc, but not paracetamol, prevents depressive-like behavior and sickness behavior, and inhibits interferon-gamma and astrogliosis in rats.

In conclusion, zinc treatment was beneficial for sickness behavior and depressive-like behavior without concomitant administration of antidepressants. IFN-gamma and GFAP were linked with the expression of sickness behavior and depressive-like behavior and were also involved with the antidepressant effects. Therefore, zinc, IFN-gamma, and GFAP pathways should be considered for depression treatment. PMID: 32006614 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32006614?dopt=Abstract

Source: Brain, Behavior, and Immunity - January 28, 2020 Category: Neurology Authors: Kirsten TB, Cabral D, Galvão MC, Monteiro R, Bondan EF, Martha Bernardi M Tags: Brain Behav Immun Source Type: research