Developing an understanding of skin picking in people with Prader-Willi syndrome: a structured literature review and re-analysis of existing data

Publication date: Available online 1 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Joyce Whittington, Anthony HollandAbstractA search of the PubMed and Web of Science databases for articles on skin picking in PWS was undertaken identifying case studies; trials of specific treatments; and descriptions of when skin picking occurs, what sites are chosen, and what initiates and sustains this behaviour. Published papers have also considered how skin picking might link to the PWS genotype and whether it is best considered to be part of the repetitive and ritualistic behaviours characteristic of the syndrome. To answer specific questions raised as a result of the review additional analysis was undertaken using data from our earlier population-based study of PWS. We consider this behaviour of skin picking using the framework of the Research Domains Criteria that is cross diagnostic and focuses on the identification of specific neurobiological, psychological and cognitive processes. PWS illustrates the likely interplay between different processes that first initiate and then maintain such behaviour. Treatment development depends on better understanding these mechanisms and their relative contribution to the behaviour.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Publication date: Available online 7 March 2020Source: Physiology &BehaviorAuthor(s): Rachel Wevrick
Source: Physiology and Behavior - Category: Physiology Source Type: research
In this study, we report an obese adolescent PWS patient of poor aerobic fitness compared with 13 obesity adolescents, and great improvement in cardiopulmonary exercise test (CPET) outcomes of the PWS patient measured after two weeks of physical exercise training programs.
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Condition:   Prader-Willi Syndrome Intervention:   Drug: OT Sponsors:   University Hospital, Toulouse;   International Clinical Trials Association;   Epidemiological and Clinical Research Information Network Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
People with Prader-Willi Syndrome (PWS) experience great difficulties in social adaptation that could be explained by disturbances in emotional competencies. However, current knowledge about the emotional func...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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Prader-Willi Syndrome (PWS) is a genetic disorder caused by the lack of expression of certain paternal genes located on chromosome 15q11-q13. This anomaly causes cognitive, neurological and endocrine abnormali...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Condition:   Prader-Willi Syndrome Interventions:   Drug: Pitolisant oral tablets;   Drug: Placebo oral tablet Sponsor:   Harmony Biosciences, LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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