Very Large Database of Lipids: Rationale and Design

Abstract Blood lipids have major cardiovascular and public health implications. Lipid‐lowering drugs are prescribed based in part on categorization of patients into normal or abnormal lipid metabolism, yet relatively little emphasis has been placed on: (1) the accuracy of current lipid measures used in clinical practice, (2) the reliability of current categorizations of dyslipidemia states, and (3) the relationship of advanced lipid characterization to other cardiovascular disease biomarkers. To these ends, we developed the Very Large Database of Lipids (NCT01698489), an ongoing database protocol that harnesses deidentified data from the daily operations of a commercial lipid laboratory. The database includes individuals who were referred for clinical purposes for a Vertical Auto Profile (Atherotech Inc., Birmingham, AL), which directly measures cholesterol concentrations of low‐density lipoprotein, very low‐density lipoprotein, intermediate‐density lipoprotein, high‐density lipoprotein, their subclasses, and lipoprotein(a). Individual Very Large Database of Lipids studies, ranging from studies of measurement accuracy, to dyslipidemia categorization, to biomarker associations, to characterization of rare lipid disorders, are investigator‐initiated and utilize peer‐reviewed statistical analysis plans to address a priori hypotheses/aims. In the first database harvest (Very Large Database of Lipids 1.0) from 2009 to 2011, there were 1 340 614 adult an...
Source: Clinical Cardiology - Category: Cardiology Authors: Tags: Trial Design Source Type: research

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CONCLUSIONS: Patients with axSpA are more likely to be reclassified into the very-high risk category after carotid ultrasound than controls. The influence of traditional cardiovascular risk factors on this reclassification differs between patients and controls. PMID: 32083538 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Conclusion: The results suggest that traditional herbal combination may safely improve glycemic control in type II diabetic patients with no significant adverse effect. PMID: 32081056 [PubMed - as supplied by publisher]
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
Publication date: Available online 23 February 2020Source: Antiviral ResearchAuthor(s): Yunhe Jiang, Shunan Liu, Siyu Shen, Haoran Guo, Honglan Huang, Wei WeiAbstractEnterovirus D68 (EV-D68) is a member of the Picornavirus family and a causative agent of respiratory diseases in children. The incidence of EV-D68 infection has increased worldwide in recent years. Thus far, there are no approved antiviral agents or vaccines for EV-D68. Here, we show that methyl-β-cyclodextrin (MβCD), a common drug that disrupts lipid rafts, specifically inhibits EV-D68 infection without producing significant cytotoxicity at virucida...
Source: Antiviral Therapy - Category: Virology Source Type: research
Researchers also reported no significant association between egg consumption and cholesterol levels.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
CONCLUSION: The concentration of sdLDL in plasma lipoprotein spectrum obtained by two different laboratory procedures was analysed, compared, evaluated and 70% identical corresponding results have been confirmed. PMID: 32087095 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence emission spectroscopy.SignificanceThe prediction of such binding affinity with metals on the active sites and its impact on the c...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Gluszewska A, Gryglewska B, Rewiuk K, Zarzycki B, Dzieza-Grudnik A, Kwater A, Major P, Budzynski A, Gasowski J, Grodzicki T Abstract Subclinical arterial damage connected with endothelial dysfunction is a common denominator of cardiovascular complications in a variety of metabolic diseases, including obesity. The aims of the study was to assess functional vascular changes measured by flow-mediated dilatation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery, and to measure vascular structural alterations estimated by carotid intima-media complex thickness (IMT) in short- (10 days) and medi...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
ConclusionsThere are elevated levels of risk for CVD in some athletes, primarily football players. Lifestyle behaviours associated with elite athleticism, particularly football linemen potentially expose players to greater metabolic and CVD risk, which is not completely offset by sport participation.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
U.S. regulators have approved a new type of cholesterol-lowering drug aimed at millions of people who don't get enough help from widely used statin pills like Lipitor and Crestor
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Publication date: Available online 21 February 2020Source: Clinica Chimica ActaAuthor(s): Wujun Chen, Yudong Wu, Qi Lu, Shuai Wang, Dongming XingAbstractApoA-I is a major protein component of high-density lipoprotein (HDL) that is widely known for regulating cholesterol trafficking and inflammatory and immune responses and for protecting against atherosclerosis. ApoA-I is generally considered to be synthesized in the liver (hepatocytes) and small intestine (enterocytes). However, computer analysis of ApoA-I has shown that the ApoA-I gene may be expressed in not only hepatocytes and enterocytes but also monocyte-macrophage ...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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