Adiponectin Levels Are Elevated in Patients With Pulmonary Arterial Hypertension

Abstract BackgroundIn addition to insulin‐sensitizing effects, adiponectin influences several mechanisms involved in pulmonary arterial hypertension (PAH) pathobiology. Insulin resistance has been associated with PAH, and elevated adiponectin levels have been described in left heart failure (HF) as a response to the increased metabolic stress. No studies have been performed in right HF or PAH patients. HypothesisCompared to healthy controls, PAH patients have a different plasma adipocytokine profile, higher insulin resistance, and higher inflammatory systemic activation. MethodsA case–control study was conducted in PAH patients individually matched for sex, age, and body mass index. We characterized the clinical features, functional status (6‐minute walking test), and hemodynamic profile of cases (n = 25). We measured insulin resistance (homeostasis model assessment and high‐density lipoprotein/triglycerides ratio), inflammatory systemic activation (high‐sensitivity C‐reactive protein), and plasma adipocytokine profile (adiponectin, leptin, visfatin, and resistin) in cases and controls. ResultsPAH patients had significantly higher adiponectin levels than controls (12.4 ± 6.9 vs 8.1 ± 4.5 µg/mL; P
Source: Clinical Cardiology - Category: Cardiology Authors: Tags: Clinical Investigation Source Type: research

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Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
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Publication date: Available online 19 February 2020Source: Journal of Cardiology CasesAuthor(s): Chiaki Goten, Soichiro Usui, Takuto Hamaoka, Tomoya Harada, Oto Inoue, Hirofumi Okada, Shin-ichiro Takashima, Takeshi Kato, Hisayoshi Murai, Kenji Sakata, Hiroshi Furusho, Masa-aki Kawashiri, Masayuki TakamuraAbstractThe prognosis of pulmonary arterial hypertension (PAH) has significantly improved over the past two decades due to advances in medications, including pulmonary vasodilators. However, the side effects of these drugs remain problematic in some patients. A 51-year-old woman with chronic hepatitis C was diagnosed with ...
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