Treatment with Synthetic Pseudo-Ceramide Improves Atopic Skin Switching the Ceramide Profile to a Healthy Skin Phenotype

Little is known about the pathophysiological linkages between altered ceramide profiles in the stratum corneum (SC) of patients with atopic dermatitis (AD) and their impaired skin barrier and water-holding functions. We studied those characteristics following topical treatment with a designed synthetic pseudo-ceramide (pCer) and analyzed that pathophysiological linkage by microanalyzing ceramides using NPLC-ESI Mass Spectrometry. Four weeks of treatment with pCer significantly reduced skin symptoms, accompanied by significant decreases in trans-epidermal water loss (TEWL) and increases in water content.

Source: Journal of Investigative Dermatology - January 31, 2020 Category: Dermatology Authors: Koichi Ishida, Akihiko Takahashi, Kotatsu Bito, Zoe Draelos, Genji Imokawa Tags: Original Article Source Type: research