Assessing the Variability and Quality of Lung Stereotactic Radiation Therapy Treatment Plans Using a Web-Based Crowdsourcing Platform

ConclusionsThese findings demonstrate the importance of quality assurance to help improve planning and contouring and the value of peer review and comparison. More readily accessible quality evaluation software solutions, such as the one used herein, may help meet this growing need.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Authors: Klement RJ PMID: 32212835 [PubMed - as supplied by publisher]
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Authors: Goto D, Komeda K, Uwatoko N, Nakashima M, Koike M, Kawai K, Kodama Y, Miyazawa A, Tanaka I, Hase T, Morise M, Hasegawa Y, Kawabe T, Sato M Abstract We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest ...
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research
Authors: Zhang P, Tao H, Yu L, Zhou L, Zhu C Abstract Injectable implants with the ability to form in situ are one of the most promising carriers for the delivery of chemotherapeutic drugs to tumor sites. We have reported a novel injectable in situ-forming implant system composed of n-butyl-2-cyanoacrylate (NBCA), ethyl oleate, along with the sol-gel phase transition. The chemotherapeutic drug-loaded injectable NBCA ethyl oleate implant (INEI) exhibited excellent therapeutic efficacy for local chemotherapy. Herein, we utilize this INEI to carry N, N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide) (TE-C-5003), whi...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Akhter MH, Kumar S, Nomani S Abstract Objective: In vitro, optimization, characterization and cytotoxic studies of NAR NPs to against pancreatic cancer.Method: The sonication tailored NARG loaded poly (lactide-co-glycolic acid) (PLGA) nanoparticle (NPs) was fabricated for potential cytotoxic effect against pancreatic cancer. NARG NPs were prepared by emulsion-diffusion evaporation technique applying Box Behnken experimental design based on 3-level and 3-factors. The effect of independent variables surfactant concentration (X1), polymer concentration (X2) and sonication time (X3) were studied on responses p...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Conclusions: In this study, the SUV of 99mTc-MDP was successfully determined using SPECT/CT. This research provides an approach that could potentially aid in the clinical quantification of radionuclide uptake in normal vertebrae for the management of breast cancer patients. PMID: 32213791 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Publication date: Available online 27 March 2020Source: Meta GeneAuthor(s): Ayushman Kumar Banerjee, Rahul Bhattacharya, Chittabrata Mal
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 27 March 2020Source: The SurgeonAuthor(s): Yen Ming Chan, Craig MacKay, Duncan T Ritchie, Neil Scott, Craig Parnaby, Graeme I. Murray, George Ramsay
Source: The Surgeon - Category: Surgery Source Type: research
ConclusionsThese findings demonstrate the importance of quality assurance to help improve planning and contouring, as well the value of peer review and comparison. More readily accessible quality evaluation software solutions, such as the one used here, may be poised to help meet this growing need.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Stereotactic ablative radiotherapy is a therapy of choice in management of early stage lung cancer. However, in 2006, RTOG 0236 phase II trial raised safety concerns for SABR of centrally located lung tumours. Other publications reinforced this hypothesis, describing partial or complete bronchial strictures, proximal bronchial tree necrosis (PBT, defined as last 2  cm of trachea, carina, right and left main bronchi and bronchial tree up to the second bifurcation), fatal haemoptysis and oesophageal fistulas, thus leading to dosimetric guidelines to avoid such severe late effects [1–5].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U.S. census region, and state. These data are important for initiation, monitoring, and evaluation of tobacco prevention and control measures. PERIOD COVERED: 2010-2014. DESCRIPTION OF SYSTEM: Cancer incidence data from CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program were used to calculate average annual age-adjusted incidence rate...
Source: MMWR Surveill Summ - Category: Epidemiology Authors: Tags: MMWR Surveill Summ Source Type: research
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