Yokukansan, a Japanese Herbal Medicine, suppresses Substance P-induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells.

CONCLUSION: Yokukansan exhibits anti-inflammatory activity by suppressing SP-induced production of IL-6 and IL-8 and downregulating COX-2 expression in U373 MG cells, possibly via inhibition of the activation of signaling molecules, such as ERK1/2, p38 MAPK, and NF-κB. PMID: 32003704 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32003704?dopt=Abstract

Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 29, 2020 Category: Endocrinology Authors: Yamaguchi K, Yamazaki S, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I Tags: Endocr Metab Immune Disord Drug Targets Source Type: research