Survival prediction models for patients with anal carcinoma receiving definitive chemoradiation: A population-based study.

Survival prediction models for patients with anal carcinoma receiving definitive chemoradiation: A population-based study. Oncol Lett. 2020 Feb;19(2):1443-1451 Authors: Wu Y, Han X, Li Y, Zhu K, Yu J Abstract The present study aimed to develop two nomograms in order to predict cancer-specific survival (CSS) and overall survival (OS) of patients with anal carcinoma receiving definitive chemoradiotherapy. Data from studies including patients with anal carcinoma, who were determined to be positive histologically and diagnosed between 2004 and 2010, were obtained from the Surveillance, Epidemiology, and End Results database. Significant prognostic factors for CSS and OS of patients were screened to develop nomograms through univariate and multivariate analyses. Nomograms were validated using internal and external data. The predictive abilities of the generated models were evaluated by concordance index (C-index) and calibration curves. Risk stratification was performed for patients with the same TNM stage. A total of 1,473 patients and six independent prognostic factors for CSS and OS, namely age, sex, ethnicity, marital status at diagnosis, T stage and N stage, were included in the nomogram calculations. Calibration curves demonstrated that nomogram prediction was in high accordance with actual observation. The C-indices of nomograms were greater than those of models based on the sixth edition of the American Joint Committee on Cancer T...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research