Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens.

CONCLUSIONS: PBL was a noninvasive source of T cells targeting TP53 mutations for cell therapy and can provide a window into intratumoral p53 neoantigen immune responses.
PMID: 31996390 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 28, 2020 Category: Cancer & Oncology Authors: Malekzadeh P, Yossef R, Cafri G, Paria BC, Lowery FJ, Jafferji M, Good ML, Sachs A, Copeland AR, Kim SP, Kivitz S, Parkhurst MR, Robbins PF, Ray S, Xi L, Raffeld M, Yu Z, Restifo NP, Somerville RPT, Rosenberg SA, Deniger DC Tags: Clin Cancer Res Source Type: research