In Vivo Protamine Titration Using Activated Coagulation Time to Neutralize Heparin Anticoagulation in Cardiac Surgery: Proof of Concept
In vivo protamine titration (IVPT) is based on the observation of a plateau on the decay curve of the celite activated clotting times (ACTs) during protamine infusion for heparin reversal. The aim of the present study was to determine the optimal protamine/heparin ratio to reverse anticoagulation using IVPT curves.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Antoine G. Rochon, Sylvain B élisle, Pierre Couture, Annik Fortier, Jean-Sébastien Lebon, Alain Deschamps Tags: Original Article Source Type: research