Uterine myomas: clinical impact and pathophysiological bases

Publication date: Available online 30 January 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Meritxell Gracia, Francisco CarmonaAbstractUterine myomas (fibroids, leiomyomas) are the most common benign myometrial tumors in women of reproductive age. They are present in 5-70% of women (depending on different series), with at least one fibroid identified in 70% of women aged 40 to 60 years. Symptoms are present in 20-50% of women with uterine fibroids and include Abnormal Uterine Bleeding (AUB), pelvic pain, Bulk-pressure symptoms and fertility problems depending on the size and location. Symptoms associated with myomas can negatively impact daily living and quality of life (QoL). However, most of women are asymptomatic. Fibroids are also the main cause of hysterectomy with a substantial impact in terms of health and quality of life in fertile women.Risk factors have been associated with the development of uterine fibroids ranging from genetic predisposition to variable lifestyle behaviours: black women have 3-fold increased relative risk and prevalence, are more likely to have severe symptoms and they tend to be younger at the time of diagnosis. Globally, uterine fibroids are associated with 10% of infertility cases and are the only identified cause of infertility in 1 to 3% of patients. The effect of uterine fibroids on infertility is largely dependent on the location of the fibroid, with submucosal and intramural fibroids having ...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research

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Authors: Brignardello-Petersen R PMID: 32245571 [PubMed - as supplied by publisher]
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Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
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Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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