What is the role of medical therapy in adrenal-dependent Cushing’s syndrome?
Publication date: Available online 31 January 2020Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Leah T. Braun, Martin ReinckeAbstractMedical therapy to control hypercortisolism in adrenal Cushing’s syndrome is currently not the first-line therapy. However, in many clinical scenarios like pre-surgical treatment, in patients who are not suitable candidates for surgery or in patients with bilateral hyperplasia, medical therapy can be important representing the only viable treatment option. Adrenal steroidogenesis inhibitors and glucocorticoid receptor blockers have been used for many years: metyrapone, ketoconazole and mifepristone are in current use and effective. Mitotane can be used as well but is considered second-line therapy because of its high toxicity. Etomidate has a special position as emergency medication in severe hypercortisolism. New drugs are tested in prospective trials (levoketoconazole, osilidrostat and relacorilant) and might become effective alternatives to common drugs. Oher drugs - adrenal steroidogenesis inhibitors as well as glucocorticoid receptor antagonists - are currently tested in vitro.
This report continues the development of ALIs as a clinical tool in wildlife while systematically testing one possible method for determining an optimal ALI for a particular species. PMID: 32228119 [PubMed - as supplied by publisher]
Authors: Park J, Kim J, Chen Y, Song HC, Chen Y, Zheng M, Surh YJ, Kim UH, Park JW, Joe Y, Chung HT Abstract Oxidative stress is recognised as a key factor that can lead to cellular senescence and aging. Carbon monoxide (CO) is produced by haemoxygenase-1 (HO-1), which exerts cytoprotective effects in aging-related diseases, whereas the effect of CO on cellular senescence and aging has not been elucidated. In the current study, we clearly demonstrated that CO delays the process of cellular senescence and aging through regulation of miR-34a and Sirt1 expression. CO reduced H2O2-induced premature senescence in human ...
Publication date: Available online 1 April 2020Source: Journal of Microbiological MethodsAuthor(s): Wisnu Tafroji, Felicia Monica Bernadette, Ernawati A. Giri Rachman, Dodi Safari
Publication date: Available online 2 April 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chun-Min Kang, Xiang-Jun Chen, Ching-Chin Chih, Chen-Ching Hsu, Ping-Hung Chen, Tai fen Lee, Lee-Jene Teng, Po-Ren Hsueh
Publication date: Available online 1 April 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chien-Yu Lee, Pi-Sheng Wang, Yuan-Der Huang, Yung-Ching Lin, Yung-Nien Hsu, Shih-Chung Chen
Publication date: Available online 1 April 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chia-Hung Liao, Shih-Chang Hung, Yuan-Ti Lee, Hung-Chang Hung, Po-Ren Hsueh
Publication date: Available online 2 April 2020Source: Statistics &Probability LettersAuthor(s): Junhao Guo, Jie Zhou, Sanfeng Hu
Publication date: Available online 1 April 2020Source: Statistics &Probability LettersAuthor(s): S. Mousavinasr, C.R. Gonçalves, C.C.Y. Dorea
Publication date: 1 May 2020Source: Sensors and Actuators A: Physical, Volume 306Author(s): Chuang Ge, Leixiang Bian, Jiayang Li, Mingyou Zhong, Songtong Han, Yunfei Jia
Publication date: Available online 1 April 2020Source: Results in PhysicsAuthor(s): U.S. Okorie, A.N. Ikot, E.O. Chukwuocha, G.J. Rampho