Erchen decoction plus huiyanzhuyu decoction inhibits the cell cycle, migration and invasion and induces the apoptosis of laryngeal squamous cell carcinoma cells
ConclusionsThese results suggest that EHD has an anticancer effect in LSCC. EHD treatment induces apoptosis and inhibits the cell cycle, migration and invasion of LSCC cells, but further work is warranted to address the mechanisms.Graphical abstract
Abstract BACKGROUND AND PURPOSE: Bilateral elective nodal irradiation (ENI) remains the standard treatment for head and neck squamous cell carcinoma (HNSCC). Unilateral ENI could reduce treatment toxicity and improve health-related quality-of-life (HRQOL). This prospective proof-of-principle trial (NCT02572661) investigated the feasibility, safety and clinical benefits of SPECT/CT-guided ENI of the node-negative contralateral neck. MATERIALS AND METHODS: Patients with lateralized T1-3N0-2bM0 HNSCC of the oropharynx, oral cavity, larynx and hypopharynx underwent SPECT/CT after peritumoral 99mTc-nanocolloid inj...
Conclusion: Our findings suggested that the SNPs (rs16879870, rs2641256, rs2761591, rs854936) might play a crucial role in prognosis of HNSCC.
Conclusions: Our study demonstrated that EGFR grading using H-score with the generated cut-off point by the ROC curve might be further applied as a potential marker for LSCC prognostic prediction. PMID: 32186231 [PubMed - as supplied by publisher]
The clinical management of head and neck squamous cell carcinoma (HNSCC) commonly involves chemoradiotherapy, but recurrences often occur that are associated with radioresistance. Using human SQD9 laryngeal squamous cell carcinoma cancer cells as a model, we aimed to identify metabolic changes associated with acquired radioresistance. In a top-down approach, matched radiosensitive and radioresistant SQD9 cells were generated and metabolically compared, focusing on glycolysis, oxidative phosphorylation (OXPHOS) and ROS production. The cell cycle, clonogenicity, tumor growth in mice and DNA damage-repair were assessed. Mitoc...
Total laryngectomy (TL) is a definitive surgical approach for larynx cancer, but may not be performed as often in the upfront setting after publication of the VA Larynx Trial in 1991. The aim of the study is to evaluate trends in the upfront utilization of TL as well as patient and oncologic factors associated with TL utilization. We hypothesized that laryngectomy rates would continue to decline with the most recent population data and that racial disparities would narrow.
Verrucous carcinoma is an uncommon, relatively indolent form of laryngeal squamous cell carcinoma. Historically, surgery has been the favored approach, due to concerns of potential anaplastic transformation and secondary metastasis theoretically associated with radiotherapy. To examine national trends in the treatment of verrucous carcinoma of the larynx, we utilized the National Cancer Database (NCDB).
To evaluate patterns of failure, toxicities, and dosimetric impact on dysphagia/aspiration risk structures (DARS) using a direct gross tumor volume (GTV70) to planning target volume expansion (dPTV70) in patients treated for laryngeal squamous cell carcinomas.
In this study, we evaluated the relationship between continued tobacco use (CU) and outcomes in patients undergoing RT, hypothesizing that CU would result in impaired outcomes.
Primary total laryngectomy (TL) is an option for patients with laryngeal cancer who are poor candidates for organ preservation. The purpose of this study was to evaluate complications, functional outcomes, and survival after primary TL for patients with laryngeal cancer.
Definitive radiation remains a treatment option for early stage glottic larynx cancer. Intensity modulated radiation therapy (IMRT) has been the standard treatment for more advanced head and neck cancers, while 3D conformal radiotherapy (3D CRT) has remained standard for early glottic cancers. We used the National Cancer Database (NCDB) to identify predictors of IMRT use and effect on outcome in these patients.