Cancers, Vol. 12, Pages 327: Treatment with Beta-Blockers and ACE-Inhibitors in Breast Cancer Patients Receiving Adjuvant Trastuzumab-Based Therapy and Developing Mild Cardiac Toxicity: A Prospective Study
Conclusion: Treatment of MCT with ACEis and BB allows faster LVEF recovery from nadir values and should be further studied in this setting.
Authors: Gomes I, de Almeida BP, Dâmaso S, Mansinho A, Correia I, Henriques S, Cruz-Duarte R, Vilhais G, Félix P, Alves P, Corredeira P, Barbosa-Morais NL, Costa L, Casimiro S Abstract The role of RANKL-RANK pathway in progesterone-driven mammary carcinogenesis and triple negative breast cancer tumorigenesis has been well characterized. However, and despite evidences of the existence of RANK-positive hormone receptor (HR)-positive breast tumors, the implication of RANK expression in HR-positive breast cancers has not been addressed before. Here, we report that RANK pathway affects the expression of cel...
In conclusion, results showed that the root extract possess the highest cytotoxicity among all other tested extracts toward both breast cancer cell lines (MCF-7 and MDA MB-231). PMID: 32479012 [PubMed - in process]
Authors: Zhang H, Lv P, Xiao Z, Jothi EA, Yang J Abstract Breast cancer is a widespread disease that affects women globally. Diagnostic processes and remedial approaches to breast carcinogenesis have improved in recent decades, but continuous survival of patients with breast carcinogenesis is still lacking due to increased cell proliferation. The aim of the present work is to explore the anticell proliferative effects of nobiletin (NOB) against 7,12-dimethylbenz[a]anthracene (DMBA)-treated mammary tumorigenesis in rats. We stimulate mammary carcinogenesis using oral gavage of DMBA (25 mg/kg body weight) mixed with ...
(Wiley) Outdoor light at night was linked to a higher risk of breast cancer in a study published in the International Journal of Cancer.
(Wiley) A new BJS (British Journal of Surgery) study indicates that breast cancer surgery is safe for patients who are older than 70 years of age, but age can influence the decision to undergo surgery.
Publication date: Available online 1 June 2020Source: Seminars in Cancer BiologyAuthor(s): Dipta Sengupta, Moonmoon Deb, Swayamsiddha Kar, Nibedita Pradhan, Sabnam Parbin, R. Kirtana, Suraj P. Singh, S.G. Suma, Niharika, Ankan Roy, Saumen Manna, Priyanka Saha, Priyanka Chakraborty, Soumya Dash, Chahat Kausar, Samir Kumar Patra
British Journal of Cancer, Published online: 03 June 2020; doi:10.1038/s41416-020-0873-zHuman Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription
British Journal of Cancer, Published online: 03 June 2020; doi:10.1038/s41416-020-0909-4Phase 2 study of cabazitaxel as second-line treatment in patients with HER2-negative metastatic breast cancer previously treated with taxanes—a Hellenic Cooperative Oncology Group (HeCOG) Trial
In conclusion, Timo AIII is potent as a compound or leading compound for further drug development while still needs in-depth studies.
ConclusionsThe HRD-high phenotype of AYA breast cancer patients can be deduced from genomic and pathological factors that are routinely examined in the oncology clinic, irrespective of germlineBRCA1/2 mutations.