Association Between Polymorphisms in DNA Damage Repair Genes and Radiation Therapy –Induced Early Adverse Skin Reactions in a Breast Cancer Population: A Polygenic Risk Score Approach

Genetic variations in DNA damage repair (DDR) genes may influence radiation therapy (RT) –induced acute normal tissue toxicity in patients with breast cancer. Identifying an individual or multiple single-nucleotide polymorphisms (SNPs) associated with RT–induced early adverse skin reactions (EASR) is critical for precision medicine in radiation oncology.

Source: International Journal of Radiation Oncology * Biology * Physics - January 29, 2020 Category: Radiology Authors: Eunkyung Lee, Sung Y. Eum, Susan H. Slifer, Eden R. Martin, Cristiane Takita, Jean L. Wright, Robert B. Hines, Jennifer J. Hu Tags: Clinical Investigation Source Type: research