Respiratory syncytial virus infection: why does disease severity vary among individuals?

This article reviews the available literature on the field of RSV disease severity and discusses important factors associated to susceptibility and different disease outcome.Expert opinion: The severity of RSV-induced illness is a phenomenon that depends on a variety of graded mechanisms of interaction between the host, virus, and environment. This may lead to differences in intensity of immune response in the lung and different courses of the disease. By characterizing, classifying and grading the affecting factors in high-risk patients versus those who do not fall ill by RSV, we may find therapies or point to disease-limiting medications. PMID: 31995408 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

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Conclusions.PID accounted for about 40% of NCFB. Early diagnosis/appropriate treatment have impact on clinical course of a PID patient. Thus, follow-up in also immunology clinics should be a routine for patients who experience pneumonia in the first year of their lives and those with NCFB. Most patients with NCFB (84.28%) had their first pulmonary infection within the first year of their lives. PMID: 32372587 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Authors: Bianchi F, Bennett D, Alderighi L, Pieroni M, Refini RM, Fossi A, Bargagli E, Mazzei MA, Guazzi G, Cusi MG, Sestini P Abstract Seven species of coronavirus cause of acute respiratory illness in humans. Coronavirus HKU 1 (CoV-HKU 1) was first described in 2005 in an adult patient with pneumonia in Hong Kong. Although it is a well-known respiratory tract pathogen, there is not much information about its role in hospitalized adults, especially in southern Europe. Here we describe a case of radiologically demonstrated CoV-HKU 1-related bronchiolitis with acute respiratory failure in an adult female without sig...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
This study also demonstrates that HRV infection upregulates PAD2 protein expression, and increases levels of protein citrullination, including histone H3, in human bronchial epithelial cells. Increased PADI gene expression and HDP citrullination during infection may represent a novel viral evasion mechanism, likely applicable to a wide range of pathogens, and should therefore be considered in the design of therapeutic peptide derivatives.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Underner M, Peiffer G, Perriot J, Jaafari N Abstract Cocaine can be responsible for many psychiatric and/or somatic disorders. The aim of this systematic literature review of data was to expose relations between cocaine use and pulmonary complications. Cocaine can be responsible for acute respiratory symptoms (cough, black sputum, hemoptysis, dyspnea, wheezing, chest pain) and for various pulmonary disorders including barotrauma (pneumothorax, pneumomediastinum, subcutaneous emphysema, pneumopericardium), airway damage, asthma, bronchiolitis obliterans with organizing pneumonia, acute pulmonary edema, alve...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Discussion The respiratory system is a complex system. The upper airways must remain patient. The lower airways must interface with the vascular system. The musculoskeletal system must provide mechanical function and the central nervous system must provide overall control. Respiratory failure occurs when the overall system cannot support the body’s necessarily ventilation, oxygenation or both. Children are at higher risk of respiratory failure. They have few intrinsic lung parenchyma problems, but have very small airways that increase the airflow resistance by themselves but then have to contend with problems such as...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection. A cause-effect relationship between HBoV and respiratory infection is not clear, so further studies are needed to clarify this point. PMID: 31776891 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research
Conclusions: The patterns of viral infections associated wiht the diagnois of ‘asthma’ and ‘wheezing illness’ are largely the same. Proper diagnosis of asthma may lead to proper asthma treatment. Most children with pneumonia were found to have a viral etiologies. Rapid detection of viral infections may help to minimize unnecessary antibiotic prescritption.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory epidemiology Source Type: research
Conclusion: Increased concentrations of a range of ambient air pollutants is associated with increased risk of unscheduled HRU for asthma and pneumonia.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and environmental health Source Type: research
Conditions:   Respiratory Distress Syndrome;   Pneumonia;   Bronchiolitis;   Croup;   Croup; False;   Asthma;   Bronchial Hyperreactivity Intervention:   Device: Telemedicine Sponsor:   Rijnstate Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Pulmonary cysts are frequently encountered at thoracic computed tomography, often incidentally detected. For patients older than 40 years of age, a few pulmonary cysts found at thoracic computed tomography can be a normal finding. The etiologies of pulmonary cysts are numerous, and cysts should be distinguished from other focal lucent lung lesions, such as the numerous causes of cavitary lung disease, bronchiectasis, honeycombing, and emphysema. When pulmonary cysts are encountered in older children or adult patients, a number of specific disorders, collectively referred to as diffuse cystic lung diseases, merit considerat...
Source: Clinical Pulmonary Medicine - Category: Respiratory Medicine Tags: Images in Pulmonary Medicine Source Type: research
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