Clinical Characteristics and Risk Factors for Complications of Candidaemia in Adults: Focus on Endophthalmitis, Endocarditis, and Osteoarticular Infections

Candidaemia is a nosocomial bloodstream infection with a high mortality rate (Asmundsdottir et al., 2002; Bassetti et al., 2014). Candida species can disseminate to various organs, causing complications that not only are difficult to treat but also require surgical intervention and cause sequelae (Kauffman, 2015). Candida endophthalmitis is the most common complication of candidaemia and occurs in 2 –16% of patients with candidaemia (Feman et al., 2002; Oude Lashof et al., 2011; Huynh et al., 2012; Geraymovych et al., 2015).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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Publication date: Available online 26 June 2020Source: IDCasesAuthor(s): Kirsten K. Prabhudas-Strycker, Saira Butt, Madhukanth T. Reddy
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 17 April 2020Source: IDCasesAuthor(s): Mariana Sousa, Joana Martins, Sara Barreto, Cristina Santos, Rita Gouveia, José Paulo Santos, Nuno Guerra, Aura Ramos
Source: IDCases - Category: Infectious Diseases Source Type: research
Candida species are common colonizers of the human skin, vagina, and the gut. As human commensals, Candida species do not cause any notable damage in healthy individuals; however, in certain conditions they can initiate a wide range of diseases such as chronic disseminated candidiasis, endocarditis, vaginitis, meningitis, and endophthalmitis. The incidence of Candida caused infections has increased worldwide, with mortality rates exceeding 70% in certain patient populations. C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei are responsible for more than 90% of Candida-related infections. Interestingly...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 9 January 2020Source: IDCasesAuthor(s): Abhimanyu Aggarwal,, Karen Hogan,, Armando Paez,AbstractAspergillus endocarditis is a rare cause of culture-negative fungal endocarditis, after Candida endocarditis. Typical risk factors include intravenous drug use, immunosuppression, prior cardiac surgery or presence of prosthetic heart valves, hematopoietic stem cell or solid organ transplantation. Common presentations include signs and symptoms consistent with endocarditis but with negative bacterial blood cultures. Here, we present a case report of a 49-year-old male without known risk factors ...
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 December 2019Source: IDCasesAuthor(s): Elham Rahmati, Adrian J. Correa, Rosemary C. She
Source: IDCases - Category: Infectious Diseases Source Type: research
Semin Respir Crit Care Med 2019; 40: 508-523 DOI: 10.1055/s-0039-1693705Central venous catheter-related bloodstream infections (CR-BSI) are a frequent event in the intensive care unit (ICU) setting. In contrast to other nosocomial infections, most risk factors for CR-BSI are linked to the device and can be prevented efficiently. Rates of CR-BSI higher than 1 per 1,000 catheter days are no longer acceptable. A continuous quality improvement program is effective to reduce them. Key elements of prevention of CR-BSI are hand hygiene, avoidance of insertion of unnecessary catheters, full sterile barrier precautions at insertion...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
We report the case of a 65-year-old woman who developed candidemia and endocarditis by C. glabrata with a newly acquired FKS mutation 24 months after successful treatment of infective endocarditis by C. glabrata with a double dosage of anidulafungin (200 mg daily) followed by oral voriconazole. Driven by high echinocandin MICs the strain taken by intraoperative cultures was further analyzed in a referral microbiology laboratory, confirming the new onset of point mutation S633P of the FKS2 gene. PMID: 31545778 [PubMed - in process]
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
;oz P Abstract PMID: 31327188 [PubMed - as supplied by publisher]
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Tags: Rev Esp Quimioter Source Type: research
Abstract Fungal endocarditis (FE) is an infrequent, but a lethal condition. Candida and Aspergillus species are the two most commonly implicated pathogenic fungi. Clinical presentation is most often that of a fever of unknown origin which is hard to differentiate from bacterial endocarditis. The diagnosis of FE is extremely challenging and now shifting towards molecular diagnostic techniques. Rapid and aggressive treatment with a combination of antifungal therapy and surgical debridement is imperative to improve outcomes. PMID: 31215523 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
Publication date: Available online 8 June 2019Source: Medical Mycology Case ReportsAuthor(s): Bastian Klemens Bauer, Arik Bernhard Schulze, Andreas Löher, Florian Reinke, Lars EckardtAbstractWe provide a review of current literature and report on a case of electronic device infective endocarditis with C. tropicalis. A 64-year-old man presented for revision of his implantable cardioverter defibrillator. Echocardiography revealed extensive vegetations attached to the Eustachian valve and in the right ventricular apex. Microbiological findings presented C. tropicalis on the explanted material. The patient refused additio...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
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