Controllable Forces for Reproducible Chronic Constriction Injury Mimicking Compressive Neuropathy in Rat Sciatic Nerve

ConclusionThe functional influences of different compressive forces recapitulate the diverse clinical symptoms involved in clinical compressive neuropathy. This controllable and reproducible model of compressive neuropathy revealed the underlying molecular mechanisms of neural degeneration and inflammation. It will lead to the future development of translational therapeutics for neuropathic pain and nerve regeneration.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research