Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine.

Carboxymethyl-botryosphaeran stabilized carbon nanotubes aqueous dispersion: A new platform design for electrochemical sensing of desloratadine. Talanta. 2020 Apr 01;210:120642 Authors: Salamanca-Neto CAR, Olean-Oliveira A, Scremin J, Ceravolo GS, Dekker RFH, Barbosa-Dekker AM, Teixeira MFS, Sartori ER Abstract The polysaccharide carboxymethyl-botryosphaeran (CMB) was used to improve the dispersion of multi-walled carbon nanotubes (MWCNTs) in water. This feature was applied in modifying a glassy carbon electrode (GCE) to construct a sensitive voltammetric sensor for the determination of desloratadine (DESL), a tricyclic antihistamine. The morphology and spectroscopic behavior of the sensor were evaluated. The modified sensor was characterized as homogeneous, and presented a higher electroactive area and a lower charge transfer resistance compared to the unmodified GCE. Using linear sweep voltammetry at 25 mV s-1, the developed sensor presented a sensitivity of 1.018 μA L μmol-1 in the linear working range of 1.99-32.9 μmol L-1, with a detection limit of 0.88 μmol L-1 of DESL in 0.10 mol L-1 potassium hydrogen-phosphate solution (pH 8.0). In addition, the sensor showed excellent repeatability with a relative standard deviation of only 1.02% for a sequence of 10 measurements. The sensor was successfully applied in the analysis of pharmaceutical preparations containing DESL, with equivalent results compared to a validated...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research