What can be done pharmacologically for a subject with severe refractory constipation-predominant irritable bowel syndrome?

What can be done pharmacologically for a subject with severe refractory constipation-predominant irritable bowel syndrome? Expert Opin Pharmacother. 2020 Jan 28;:1-2 Authors: Bassotti G PMID: 31990590 [PubMed - as supplied by publisher]
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research