Role of Laparoscopy in the Diagnosis of Genital TB in Infertile Females in the Era of Molecular Tests

ConclusionPCR as a stand-alone diagnostic test for endometrial TB is not justified to confirm diagnosis and initiate ATT. The addition of laparohysteroscopy improves diagnostic yield for genital TB. Referring patients with a suspicion of female genital TB to tertiary care for 1-time laparoscopy is better than initiating ATT solely on the basis of PCR results.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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ConclusionPCR as a stand-alone diagnostic test for endometrial tuberculosis is not justified to confirm diagnosis and initiate ATT. Addition of laparo-hysteroscopy improves diagnostic yield for genital tuberculosis. Referring patients with a suspicion of FGTB to tertiary care for one time laparoscopy is better than initiating ATT based only on PCR results.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
To assess diagnostic value of polymerase chain reaction (PCR) in endometrial aspirates (EAs) in comparison with conventional tests for diagnosis of female genital tuberculosis (TB) and to find agreement between EA PCR done for endometrial TB and laparoscopic findings of pelvic TB in women with unexplained infertility.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Original Article Source Type: research
CONCLUSION: While evaluating infertile women for tubal disease, culture studies revealed a high prevalence of NTM organisms in the endometrium. In the absence of MTB, gonococci and Chlamydia infection, the presence of NTM organisms suggests the possibility that these organisms may be responsible for tubal damage leading to infertility. This article is protected by copyright. All rights reserved. PMID: 31074566 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Publication date: November–December 2018Source: Journal of Minimally Invasive Gynecology, Volume 25, Issue 7, SupplementAuthor(s): T. Goel, J.B. Sharma, R. Mahey, G. Kachhawa, I. Kriplani, A. Kriplani
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Objective: To visualize and assess the laparoscopic and hysteroscopic findings in genital tuberculosis before and after Anti-Tubercular Treatment (ATT).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatme...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
ConclusionsA strong clinical suspicion aided with multiplex PCR using menstrual blood may significantly reduce the diagnostic dilemma for GTB diagnosis in a non-invasive, sensitive, rapid, and cost-effective manner.
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research
All IVF patients know that which clinic they select for doing their IVF treatment can have a big impact on the outcome of their cycle, and this is why they spend a lot of energy and time in shopping around for the right IVF doctor. Unfortunately, a lot of them are not really sophisticated enough to be able to differentiate a good doctor and a bad doctor, and most will end up going to whichever IVF clinic their family doctor sends them to. In the past, you could trust that your family doctor would send you to a good clinic, but as we all know, this is no longer a reliable method for selecting an IVF clinic , because the med...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
"Effect of Antitubercular Therapy on Endometrial Function in Infertile Women with Female Genital Tuberculosis". Infect Disord Drug Targets. 2015 Dec 22; Authors: Sharma JB Abstract OBJECTIVE: Evaluation of anti-tubercular therapy on endometrium in Female Genital Tuberculosis Method: Total of 50 women having FGTB on endometrial aspirate (positive AFB, epitheloid granuloma, positive PCR, laparoscopy or hysteroscopy findings) were enrolled. Ultrasound was performed for endometrial thickness, mean resistive index and pulsatility index before and after anti-tuberculous therapy (ATT). Diagnostic h...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
Mycobacterial infection of the genital tract is a common etiology for female infertility in developing countries. Aim of this study is to evaluate plethora of laparoscopic and hysteroscopic appearances of tuberculosis, to correlate them with Endometrial TB PCR and BACTEC culture .
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Oral Presentation Source Type: research
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