Renin-angiotensin-aldosterone system and migraine: a systematic review of human studies.
Renin-angiotensin-aldosterone system and migraine: a systematic review of human studies.
Protein Pept Lett. 2020 Jan 29;:
Authors: Sassi KLM, Martins LB, de Miranda AS, Teixeira AL
Abstract
Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We carried out a systematic review of the studies evaluating the involvement of RAS in patients with migraine. There is evidence from genetic studies exploring the relation between migraine and RAS-related genes and from clinical trials evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the pathophysiology of migraine, but more direct evidence is still missing.
PMID: 31995000 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Sassi KLM, Martins LB, de Miranda AS, Teixeira AL Tags: Protein Pept Lett Source Type: research
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