Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation

AbstractCancer cells adapted to the microenvironment in tumor such as hypoxic and nutrient-starved conditions are now paid much attention as the therapeutic target of cancer. In the course of search for selective cytotoxic substances against cancer cells adapted to nutrient starvation, xanthone derivative of secalonic acid D (1) was isolated from culture extract of marine-derivedPenicillium oxalicum. Compound1 showed cytotoxic activity on the human pancreatic carcinoma PANC-1 cells adapted to glucose-starved conditions with IC50 value of 0.6  µM, whereas IC50 value of compound1 against PANC-1 cells under general culture conditions was calculated to be more than 1000  µM. Further study indicated that compound1 inhibited the Akt signaling pathway under glucose-starved conditions, and slightly affected the induction of glucose-regulated protein 78 (GRP78), and these effects would be mediated by the uncoupling action of compound1 on the mitochondria.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research