[Clarification of the method used for drug dosage adjustment in patients with renal failure: The CLEAR study].

CONCLUSION: The majority of summaries of product characteristics do not mention the Cockcroft-Gault formula and in the majority of cases it is not possible to identify the formula or technique used in the studies on which is based the reference to dosage adjustment in the summarie of product characteristics. In addition, there are discrepancies between the wording of the summaries of product characteristics and the data from development studies. The use of Cockcroft-Gault for dosage adjustment is to be questioned, especially since the Isotope-dilution mass spectrometry, or IDMS, standardization of creatinine dosage makes obsolete studies based on Cockcroft-Gault formula and a non-standardized dosage, and thus the use of Cockcroft-Gault not transposable to current clinical practice. PMID: 31987727 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31987727?dopt=Abstract

Source: Nephrologie and Therapeutique - January 23, 2020 Category: Urology & Nephrology Authors: Berdougo J, Delorière É, Deray G, Launay-Vacher V Tags: Nephrol Ther Source Type: research