Increased Capsaicin Sensitivity in Severe Asthmatics Associated with Worse Clinical Outcome.

Increased Capsaicin Sensitivity in Severe Asthmatics Associated with Worse Clinical Outcome. Am J Respir Crit Care Med. 2020 Jan 28;: Authors: Kanemitsu Y, Fukumitsu K, Kurokawa R, Takeda N, Suzuki M, Yap J, Nishiyama H, Tajiri T, Fukuda S, Uemura T, Ohkubo H, Maeno K, Ito Y, Oguri T, Takemura M, Niimi A Abstract RATIONALE: Capsaicin cough reflex sensitivity (C-CS) is associated with poorly controlled asthma, while its association with severe asthma remains unknown. OBJECTIVES: To determine the clinical impact of C-CS on severe asthma. METHODS: We prospectively enrolled 157 asthmatic patients (including 122 severe asthma patients who were in step 4/5 according to the GINA 2015 guideline) between November 2016 and October 2019. Capsaicin cough challenge was performed along with spirometry and assessment of biomarkers. The concentration required to induce at least five coughs by capsaicin (defined as C5) was adopted as an index of C-CS. Asthma control test (ACT) and comorbidities were also evaluated. Associations of biomarkers with 4 clinical features of severe asthma made by the ERS/ATS guideline [poor control (ACT
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research

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