AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice

Allograft vasculopathy (AV) is the main limiting factor for long-term graft survival. Increased activity of matrix metalloproteinases (MMPs) contributes to neointima formation in AV and represents a potential therapeutic target. Adeno associated viral (AAV) gene therapy comprises a potentially benign vector model for long-term expression of MMP antagonists.

Source: The Journal of Heart and Lung Transplantation - January 28, 2020 Category: Transplant Surgery Authors: Anca Remes, Maximilian Franz, Marcin Zaradzki, Christopher Borowski, Norbert Frey, Matthias Karck, Klaus Kallenbach, Oliver J. M üller, Andreas H. Wagner, Rawa Arif Source Type: research