Platelet aggregation and response to aspirin therapy in cardiac allograft vasculopathy

Long-term survival following heart transplantation (HTx) is compromised by cardiac allograft vasculopathy (CAV) characterized by coronary macro and microvascular disease. The pathogenesis of CAV is unclear and may involve coronary thrombosis. We investigated whether HTx patients with CAV had higher platelet aggregation and turnover than HTx patients without CAV and healthy controls. Furthermore, we investigated the antiplatelet effect of low-dose aspirin in HTx patients.

Source: The Journal of Heart and Lung Transplantation - January 28, 2020 Category: Transplant Surgery Authors: Kamilla Pernille Bjerre, Tor Skibsted Clemmensen, Katrine Berg, Steen Hvitfeldt Poulsen, Anne-Mette Hvas, Erik Lerkevang Grove, Brian Bridal L øgstrup, Lars Jakobsen, Troels Thim, Steen Dalby Kristensen, Hans Eiskjær Source Type: research