Immune Consequences of Endothelial Cells ’ Activation and Dysfunction During Sepsis
The vascular endothelium provides a direct interface between circulating blood cells and parenchymal cells. Thus, it has a key role in vasomotor tone regulation, primary hemostasis, vascular barrier, and immunity. In the case of systemic inflammation, endothelial cell (EC) activation initiates a powerful innate immune response to eliminate the pathogen. In some specific conditions, ECs may also contribute to the activation of adaptive immunity and the recruitment of antigen-specific lymphocytes. However, the loss of EC functions or an exaggerated activation of ECs during sepsis can lead to multiorgan failure.
Source: Critical Care Clinics - Category: Intensive Care Authors: St éphanie Pons, Marine Arnaud, Maud Loiselle, Eden Arrii, Elie Azoulay, Lara Zafrani Source Type: research
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