Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation

Publication date: February 2020Source: The Lancet Haematology, Volume 7, Issue 2Author(s): Olaf Penack, Monia Marchetti, Tapani Ruutu, Mahmoud Aljurf, Andrea Bacigalupo, Francesca Bonifazi, Fabio Ciceri, Jan Cornelissen, Ram Malladi, Rafael F Duarte, Sebastian Giebel, Hildegard Greinix, Ernst Holler, Anita Lawitschka, Stephan Mielke, Mohamad Mohty, Mutlu Arat, Arnon Nagler, Jakob Passweg, Hélène SchoemansSummaryGraft-versus-host disease (GVHD) is a major factor contributing to mortality and morbidity after allogeneic stem-cell transplantation. Because of the small number of results from well designed, large-scale, clinical studies there is considerable variability in the prevention and treatment of GVHD worldwide. In 2014, to standardise treatment approaches the European Society of Blood and Marrow Transplantation published recommendations on the management of GVHD in the setting of HLA-identical sibling or unrelated donor transplantation in adult patients with haematological malignancies. Here we update these recommendations including the results of study published after 2014. Evidence was searched in three steps: first, a widespread scan of published trials, meta-analyses, and systematic reviews; second, expert opinion was added for specific issues following several rounds of debate; and third, a refined search to target debated or rapidly updating issues. On the basis of this evidence and the 2014 recommendations, five members of the EBMT Transplant Complications Working...
Source: The Lancet Haematology - Category: Hematology Source Type: research